Article

Multiomic profiling of hypoxic glioblastoma stem cells reveals expansion of subpopulations with distinct epigenetic and CNV profiles

2025-05-09

Abstract excerpt

Glioblastoma is characterized by extensive intratumoral heterogeneity driven by dynamic mi-croenvironmental cues such as hypoxia. While transcriptional and epigenetic variability have been separately linked to hypoxia responses, the integrated impact of hypoxia on gene regulation and clonal architecture in glioblastoma stem cells (GSCs) remains poorly defined. We applied singlenucleus multi-omics—integrating RNA-s...

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Literature Corpus work: c41590a7-64b8-58e0-857d-9caacb3d3452
DOI: 10.1101/2025.05.05.652238

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