Article

ClonoScreen3D-CRISPRi Uncovers Genetic Modifiers of Radiation Response in Glioblastoma

2026-04-21

Abstract excerpt

<h4>Background</h4> Glioblastoma (GBM) is the most aggressive primary brain tumor in adults. Radioresistance, partly mediated by glioma stem-like cells, represents a major clinical challenge which could be overcome by the identification of the modulators of radioresistance. Existing CRISPR screens in human GBM models have largely used two-dimensional cultures with short-term viability readouts, failing to capture...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e9f79725-0a53-5486-8f49-f1684869bdea
DOI: 10.64898/2026.04.17.719014

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ClonoScreen3D-CRISPRi Uncovers Genetic Modifiers of Radiation Response in GlioblastomaDOI 10.64898/2026.04.17.719014Read

DNA-PKcs inhibition sensitizes glioblastoma to radiotherapy through reprogramming of tumor cell states and immune microenvironment cell typesSemantic proximity Read

ClonoScreen3D: a novel three-dimensional clonogenic screening platform for identification of radiosensitizers for glioblastomaSemantic proximity Read

CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in gliomaSemantic proximity Read

Selective Inhibition of Parallel DNA Damage Response Pathways Optimizes Radiosensitization of Glioblastoma Stem-like CellsSemantic proximity Read

Chronically radiation-exposed survivor glioblastoma cells display poor response to Chk1 inhibitionSemantic proximity Read

Single-Cell Multiomic Profiling Uncovers Radiation Dosage-Sensitive, Cluster-Specific Regulatory Dynamics in GlioblastomaSemantic proximity Read

In vivo perturb-seq of cancer and microenvironment cells dissects oncologic drivers and radiotherapy responses in glioblastomaSemantic proximity Read

Integrated genetic screening reveals FEN1 as a driver of stemness and temozolomide resistance in glioblastomaSemantic proximity Read

Radiation-Induced Cellular Plasticity: A Strategy for Combatting GlioblastomaSemantic proximity Read

In vivo perturb-seq of cancer and microenvironment cells dissects oncologic drivers and radiotherapy responses in glioblastomaSemantic proximity Read

BRD9 inhibition induces selective radiosensitivity in glioblastoma through MYC pathway modulationSemantic proximity Read

Epigenomic perturbation of novel <i>EGFR</i> enhancers reduces the proliferative and invasive capacity of glioblastoma and increases sensitivity to temozolomideSemantic proximity Read