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Article

Human Stem Cell-Derived Neurons: A System to Study Human Tau Function and Dysfunction

11 Nov 2010

Abstract excerpt

BACKGROUND: Intracellular filamentous deposits containing microtubule-associated protein tau constitute a defining characteristic of many neurodegenerative disorders. Current experimental models to study tau pathology in vitro do not usually recapitulate the tau expression pattern characteristic of adult human brain. In this study, we have investigated whether human embryonic stem cell-derived neurons could be a...

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PMID: 21085657
DOI: 10.1371/journal.pone.0013947

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