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Article

Most regulatory interactions are not in linkage disequilibrium

2018-02-26

Abstract excerpt

Linkage disequilibrium (LD) and genomic proximity are commonly used to map non-coding variants to genes, despite increasing examples of causal variants outside the LD block of the gene they regulate. We compared chromatin contacts in 22 cell types to LD across billions of pairs of loci in the human genome and found no concordance, even at genomic distances below 25 kilobases where both tend to be high. Gene expres...

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Identifiers and source

Literature Corpus work
d62d3f84-dfe4-5df9-860a-c7977ee0131f
DOI
10.1101/272245
Open publication

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Most regulatory interactions are not in linkage disequilibriumDOI 10.1101/272245
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