Article

High resolution genetic mapping of causal regulatory interactions in the human genome

2017-11-30

Abstract excerpt

Physical interaction of distal regulatory elements in three-dimensional space poses a significant challenge for studies of common disease, because noncoding risk variants may be substantial distances from the genes they regulate. Experimental methods to capture these interactions, such as chromosome conformation capture (CCC), usually cannot assign causal direction of effect between regulatory elements, an importa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9f1346dd-e9ad-5f47-b984-67f35ada8739
DOI: 10.1101/227389

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

High resolution genetic mapping of causal regulatory interactions in the human genomeDOI 10.1101/227389Read

A New Approach for Discovering Functional Links Connecting Non-Coding Regulatory Variants to Gene TargetsSemantic proximity Read

Multiple Causal Variants Underlie Genetic Associations in HumansSemantic proximity Read

Genome-wide maps of enhancer regulation connect risk variants to disease genesSemantic proximity Read

Endogenous fine-mapping of functional regulatory elements in complex genetic lociSemantic proximity Read

Most regulatory interactions are not in linkage disequilibriumSemantic proximity Read

Efficient and accurate causal inference with hidden con-founders from genome-transcriptome variation dataSemantic proximity Read

Multiple causal variants underlie genetic associations in humans.Semantic proximity Read

Genomic approaches for understanding the genetics of complex disease.Semantic proximity Read

Genome-wide enhancer maps link risk variants to disease genes.Semantic proximity Read

Genetic and epigenetic fine mapping of causal autoimmune disease variants.Semantic proximity Read

Haplotype rather than single causal variants effects contribute to regulatory gene expression associations in human myeloid cellsSemantic proximity Read

Using chromatin marks to interpret and localize genetic associations to complex human traits and diseases.Semantic proximity Read