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Reduced nephron endowment in the common <i> Six2-TGC <sup>tg</sup> </i> mouse line is due to <i>Six3</i> misexpression by aberrant enhancer-promoter interactions in the transgene

2023-10-09

Abstract excerpt

Lifelong kidney function relies on the complement of nephrons generated during mammalian development from a mesenchymal nephron progenitor cell (NPC) population. Low nephron endowment confers increased susceptibility to chronic kidney disease. We asked whether reduced nephron numbers in the popular Six2TGC transgenic mouse line 1 was due to disruption of a regulatory gene at the integration site or to ectopic ex...

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Identifiers and source

Literature Corpus work
d62708d2-b026-531d-81ba-929591dfee90
DOI
10.1101/2023.10.06.561202
Open publication

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Reduced nephron endowment in the common <i> Six2-TGC <sup>tg</sup> </i> mouse line is due to <i>Six3</i> misexpression by aberrant enhancer-promoter interactions in the transgeneDOI 10.1101/2023.10.06.561202
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