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Article

Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulators

15 Feb 2016

Abstract excerpt

Nephron endowment is determined by the self-renewal and induction of a nephron progenitor pool established at the onset of kidney development. In the mouse, the related transcriptional regulators Six1 and Six2 play non-overlapping roles in nephron progenitors. Transient Six1 activity prefigures, and is essential for, active nephrogenesis. By contrast, Six2 maintains later progenitor self-renewal from the onset of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 26884396
DOI: 10.1242/dev.127175

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Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulatorsPMID 26884396Read ↗

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