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Identification and Characterization of the Wilms Tumor Cancer Stem Cell

28 Apr 2023

Abstract excerpt

A nephrogenic progenitor cell (NP) with cancer stem cell characteristics driving Wilms tumor (WT) using spatial transcriptomics, bulk and single cell RNA sequencing, and complementary in vitro and transplantation experiments is identified and characterized. NP from WT samples with NP from the developing human kidney is compared. Cells expressing SIX2 and CITED1 fulfill cancer stem cell criteria by reliably...

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PMID: 37114795
DOI: 10.1002/advs.202206787

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