Article

Aberrant neuron-OPC synaptic transmission and deficient myelination define sex bias in major depressive disorder

2026-06-16

Abstract excerpt

Sex bias is a notable feature of major depressive disorder (MDD), yet its cellular and molecular origins remain unclear. We integrated computational analyses of human patient data with histological and biochemical validation in animal models to uncover female-specific MDD pathways. We identified female-specific mechanisms involving oligodendroglial lineage cells, especially oligodendrocyte precursor cells (OPCs),...

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Literature Corpus work: d6216331-625b-54f2-8785-6b6e9bbd2cf0
DOI: 10.64898/2026.06.14.732204

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