Article

The Long Noncoding RNA FEDORA is a Cell-Type- and Sex-Specific Regulator of Depression

2021-12-01

Abstract excerpt

Women suffer from depression at twice the rate of men, but the underlying molecular mechanisms are poorly understood. Here, we identify dramatic baseline sex differences in expression of long noncoding RNAs (lncRNAs) in human postmortem brain tissue that are profoundly lost in depression. One such lncRNA, RP11-298D21.1 (which we termed FEDORA), is enriched in oligodendrocytes and neurons and upregulated in several...

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Literature Corpus work: 4fd145f5-d52f-5b9e-a076-0efc113b425c
DOI: 10.1101/2021.11.30.470628

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