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Article

Dissecting the genetic association between abnormal sperm parameters and depression: a transcriptome-wide analysis of 157 participants.

Journal of assisted reproduction and genetics - 1 Jun 2025

Chen Yinwei, Sun Taotao, Yuan Penghui, Liu Chang

Abstract excerpt

PURPOSE: Depression often occurs in the males with semen abnormalities. Evidence suggested a genetic correlation between depression and the pathogenesis of abnormal sperm parameters, whereas the mechanisms remained unclear. METHODS: Genomic datasets of major depressive disorder (MDD) and abnormal sperm parameters were obtained from the Gene Expression Omnibus database. After screening the datasets, differentially...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40263245
DOI: 10.1007/s10815-025-03470-0
PMCID: PMC12229347

Genes

CNDP2
LGALS3BP
PI3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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