Article

Transcriptional Heterogeneity Reveals a Synaptic Gene Program in Developing and Adult Human Oligodendrocyte Precursor Cells

2026-01-02

Abstract excerpt

Human oligodendrocyte precursor cells (OPCs) arise early in gestation and expand broadly during cortical development, yet the extent of their heterogeneity remains poorly defined. Here, we isolated >2,300 highly pure OPCs from post-conceptional week (PCW) 17 human cortex using an optimized PDGFRα-based immunopanning and performed single-cell RNA sequencing. Unsupervised clustering revealed four transcriptionally d...

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Literature Corpus work: 65d86d94-654a-507d-b1f9-b83d7df9c462
DOI: 10.64898/2026.01.01.697017

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