Article

A screen of 1,049 schizophrenia and 30 Alzheimer’s-associated variants for regulatory potential

2018-10-19

Abstract excerpt

Recent genome-wide association studies (GWAS) identified numerous schizophrenia (SZ) and Alzheimer’s disease (AD) associated loci, most outside protein-coding regions and hypothesized to affect gene transcription. We used a massively parallel reporter assay (MPRA) to screen, 1,049 SZ and 30 AD variants in 64 and 9 loci respectively for allele differences in driving reporter gene expression. A library of synthetic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d6150953-85ac-5f19-a6b4-23eeb246ed53
DOI: 10.1101/447557

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A screen of 1,049 schizophrenia and 30 Alzheimer’s-associated variants for regulatory potentialDOI 10.1101/447557Read

Systematic investigation of allelic regulatory activity of schizophrenia-associated common variantsSemantic proximity Read

Context-specific expression quantitative trait loci dynamics uncover genetic pleiotropy in schizophrenia.Semantic proximity Read

The Oft-Overlooked Massively Parallel Reporter Assay: Where, When, and Which Psychiatric Genetic Variants are Functional?Semantic proximity Read

Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay.Semantic proximity Read

An integrative functional genomics approach for discovering biomarkers in schizophrenia.Semantic proximity Read

Genome-wide discovery of multiple sclerosis genetic risk variant allelic regulatory activity.Semantic proximity Read

A functional schizophrenia-associated genetic variant near the TSNARE1 and ADGRB1 genes.Semantic proximity Read

A Functional Schizophrenia-associated genetic variant near the <i>TSNARE1</i> and <i>ADGRB1</i> genesSemantic proximity Read

Massively parallel reporter assay investigates shared genetic variants of eight psychiatric disorders.Semantic proximity Read

Identification of functional non-coding variants affecting Alzheimer’s disease risk by Massively Parallel Reporter AssaySemantic proximity Read

A role for noncoding variation in schizophrenia.Semantic proximity Read

Transcriptional-Regulatory Convergence Across Functional MDD Risk Variants Identified by Massively Parallel Reporter AssaysSemantic proximity Read