Article
A functional schizophrenia-associated genetic variant near the TSNARE1 and ADGRB1 genes.
HGG advances - 18 Jul 2024
Wahbeh Marah H, Boyd Rachel J, Yovo Christian, Rike Bailey, McCallion Andrew S, Avramopoulos Dimitrios
Abstract excerpt
Recent collaborative genome-wide association studies (GWAS) have identified >200 independent loci contributing to risk for schizophrenia (SCZ). The genes closest to these loci have diverse functions, supporting the potential involvement of multiple relevant biological processes, yet there is no direct evidence that individual variants are functional or directly linked to specific genes. Nevertheless, overlap with...
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