Article

Transcriptional-Regulatory Convergence Across Functional MDD Risk Variants Identified by Massively Parallel Reporter Assays

2021-03-07

Abstract excerpt

<h4>ABSTRACT</h4> Family and population studies indicate clear heritability of major depressive disorder (MDD), though its underlying biology remains unclear. The majority of single-nucleotide polymorphism (SNP) linkage blocks associated with MDD by genome-wide association studies (GWASes) are believed to alter transcriptional regulators (e.g., enhancers, promoters), based on enrichment of marks correlated with t...

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Literature Corpus work: b5245171-e00e-519a-ab56-477f7fa9b0a8
DOI: 10.1101/2021.03.05.434177

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