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Article

Massively parallel reporter assay investigates shared genetic variants of eight psychiatric disorders.

Cell - 6 Mar 2025

Lee Sool, McAfee Jessica C, Lee Jiseok, Gomez Alejandro, Ledford Austin T, Clarke Declan, Min Hyunggyu, Gerstein Mark B, Boyle Alan P, Sullivan Patrick F, Beltran Adriana S, Won Hyejung

Abstract excerpt

A meta-genome-wide association study across eight psychiatric disorders has highlighted the genetic architecture of pleiotropy in major psychiatric disorders. However, mechanisms underlying pleiotropic effects of the associated variants remain to be explored. We conducted a massively parallel reporter assay to decode the regulatory logic of variants with pleiotropic and disorder-specific effects. Pleiotropic...

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Identifiers

PMID: 39848247
DOI: 10.1016/j.cell.2024.12.022
PMCID: PMC11890967

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