Article

Modelling anti-tumor immune responses using patient-derived melanoma organoids

2025-09-09

Abstract excerpt

<title>Abstract</title> <p>Immune checkpoint blockade (ICB) therapy can restore T cell function in tumors, but not all patients benefit, and the mechanisms behind this remain unclear. In this study, we used patient-derived organotypic (PDO) cultures from metastatic melanoma to examine transcriptomic and cellular changes following ex vivo T cell stimulation. Genomic and transcriptomic features were preserved durin...

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Literature Corpus work: d601709a-0bdc-5c36-86cd-3c27a134240a
DOI: 10.21203/rs.3.rs-7486809/v1

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