Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Matched three-dimensional organoids and two-dimensional cell lines of melanoma brain metastases mirror response to targeted molecular therapy.

Scientific reports - 22 Oct 2024

Hicks William H, Gattie Lauren C, Shami Mohamad El, Traylor Jeffrey I, Davar Diwakar, Najjar Yana G, Richardson Timothy E, McBrayer Samuel K, Abdullah Kalil G

Abstract excerpt

Despite advances in the treatment paradigm for patients with metastatic melanoma, melanoma brain metastasis (MBM) continues to represent a significant treatment challenge. The study of MBM is limited, in part, by shortcomings in existing preclinical models. Surgically eXplanted Organoids (SXOs) are ex vivo, three-dimensional cultures prepared from primary tissue samples with minimal processing that recapitulate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Melanoma

Share to Molecular Targeted Therapy

Share to Mutation

Share to Organoids

Share to Proto-Oncogene Proteins B-raf

Source

Open in PubMed Open full text

Identifiers

PMID: 39438602
DOI: 10.1038/s41598-024-76583-8
PMCID: PMC11496643

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Matched three-dimensional organoids and two-dimensional cell lines of melanoma brain metastases mirror response to targeted molecular therapy.PMID 39438602Read ↗

Melanoma Brain Metastases Patient-Derived Organoids: an <em>in Vitro</em> Platform for Drug ScreeningSemantic proximity Read ↗

Pre-clinical modeling of cutaneous melanomaSemantic proximity Read ↗

Characterization of Uveal Melanoma Cell Lines and Primary Tumor Samples in 3D CultureSemantic proximity Read ↗

A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of MelanomaSemantic proximity Read ↗

The preliminary study of patient-derived metastatic brain tumors in a highly mimetic ex vivo spheroid-based physiological model for clinical precision therapeuticsSemantic proximity Read ↗

Sarcoma Spheroids and Organoids—Promising Tools in the Era of Personalized MedicineSemantic proximity Read ↗

Decoding molecular programs in melanoma brain metastasesSemantic proximity Read ↗

Recapitulating Tumorigenesis in vitro: Opportunities and Challenges of 3D BioprintingSemantic proximity Read ↗

Modelling anti-tumor immune responses using patient-derived melanoma organoidsSemantic proximity Read ↗

Advancing Glioblastoma Research with Innovative Brain Organoid-Based ModelsSemantic proximity Read ↗

Advances in Tumor Organoids for the Evaluation of Drugs: A Bibliographic ReviewSemantic proximity Read ↗

Establishment of an orthotopic patient-derived xenograft mouse model using uveal melanoma hepatic metastasis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.