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A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma

1 Nov 2017

Abstract excerpt

Therapy of advanced melanoma is changing dramatically. Following mutational and biological subclassification of this heterogeneous cancer, several targeted and immune therapies were approved and increased survival significantly. To facilitate further advancements through pre-clinical in vivo modeling, we have established 459 patient-derived xenografts (PDX) and live tissue samples from 384 patients representing...

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PMID: 29141225
DOI: 10.1016/j.celrep.2017.10.021

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