Article

Autophagy in parvalbumin interneurons is required for inhibitory transmission and memory via regulation of synaptic proteostasis

2022-10-10

Abstract excerpt

<h4>Summary</h4> With the emerging role of the autophagic machinery in healthy brain development and aging, there is a pressing need to better characterize its functions in different neuronal populations, providing cellular insight into autophagy-related brain diseases. Here, we generated and characterized mice with conditional ablation of atg5 in GABAergic neurons expressing parvalbumin ( PV-atg5KO ), mostly c...

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Literature Corpus work: d5f936d4-c965-5558-9ab5-4509d9e164ea
DOI: 10.1101/2022.10.10.511533

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