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Article

Turning garbage into gold: Autophagy in synaptic function

11 Dec 2024

Abstract excerpt

Trillions of synapses in the human brain enable thought and behavior. Synaptic connections must be established and maintained, while retaining dynamic flexibility to respond to experiences. These processes require active remodeling of the synapse to control the composition and integrity of proteins and organelles. Macroautophagy (hereafter, autophagy) provides a mechanism to edit and prune the synaptic proteome....

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PMID: 39667255
DOI: 10.1016/j.conb.2024.102937

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