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Autophagy controls the induction and developmental decline of NMDAR-LTD through endocytic recycling

12 Jun 2020

Abstract excerpt

NMDA receptor-dependent long-term depression (NMDAR-LTD) is a long-lasting form of synaptic plasticity. Its expression is mediated by the removal of AMPA receptors from postsynaptic membranes. Under basal conditions, endocytosed AMPA receptors are rapidly recycled back to the plasma membrane. In NMDAR-LTD, however, they are diverted to late endosomes for degradation. The mechanism for this switch is largely...

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PMID: 32532981
DOI: 10.1038/s41467-020-16794-5

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