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Article

Knockout of Atg5 delays the maturation and reduces the survival of adult-generated neurons in the hippocampus

3 Mar 2016

Abstract excerpt

Autophagy is an evolutionarily conserved lysosomal degradation pathway that plays important roles in cell maintenance, expansion and differentiation. Removal of genes essential for autophagy from embryonic neural stem and precursor cells reduces the survival and inhibits neuronal differentiation of adult-generated neurons. No study has modified autophagy within the adult precursor cells, leaving the...

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PMID: 26938300
DOI: 10.1038/cddis.2015.406

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