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Multi-omics study reveals differential expression and phosphorylation of autophagy-related proteins in autism spectrum disorder

29 Mar 2025

Abstract excerpt

Our multi-omics study investigated the molecular mechanisms underlying autism spectrum disorder (ASD) using Shank3 Δ 4–22 and Cntnap2 −/− mouse models. Through global- and phospho- proteomics of the mouse cortex, we focused on shared molecular changes and found that autophagy was particularly affected in both models. Global proteomics identified a small number of differentially expressed proteins that...

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PMID: 40158064
DOI: 10.1038/s41598-025-95860-8

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