Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GABARAPs dysfunction by autophagy deficiency in adolescent brain impairs GABA A receptor trafficking and social behavior

5 Apr 2019

Abstract excerpt

receptor levels. Our work demonstrates a novel physiological role for autophagy in regulating GABA signaling beyond postnatal neurodevelopment, providing a potential mechanism for the reduced inhibitory inputs observed in neurodevelopmental and neuropsychiatric disorders with mTOR hyperactivation.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Genetics and Neurodevelopmental Disorders
Share to Neuroscience and Neuropharmacology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30989111
DOI: 10.1126/sciadv.aau8237

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GABARAPs dysfunction by autophagy deficiency in adolescent brain impairs GABA A receptor trafficking and social behaviorPMID 30989111Read ↗

Role of mTOR‐regulated autophagy in spine pruning defects and memory impairments induced by binge‐like ethanol treatment in adolescent miceSemantic proximity Read ↗

Autophagy defects at weaning impair complement-dependent synaptic pruning and induce behavior deficits.Semantic proximity Read ↗

RAB39B Deficiency Impairs Learning and Memory Partially Through Compromising AutophagySemantic proximity Read ↗

Autophagy controls the induction and developmental decline of NMDAR-LTD through endocytic recyclingSemantic proximity Read ↗

Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defectsSemantic proximity Read ↗

Regulation of excitatory presynaptic activity by Ambra1 protein determines neuronal networks in sex-dimorphic mannerSemantic proximity Read ↗

GABA(A) receptor membrane trafficking regulates spine maturity.Semantic proximity Read ↗

BDNF controls cognitive processes related to neuropsychiatric manifestations via autophagic regulation of p62 and GABA <sub>A</sub> receptor traffickingSemantic proximity Read ↗

Chemogenetic rectification of the inhibitory tone onto hippocampal neurons reverts autistic-like traits and normalizes local expression of estrogen receptors in the Ambra1+/- mouse model of female autism.Semantic proximity Read ↗

mTOR Suppresses Macroautophagy During Striatal Postnatal Development and Is Hyperactive in Mouse Models of Autism Spectrum DisordersSemantic proximity Read ↗

Heterozygous Ambra1 Deficiency in Mice: A Genetic Trait with Autism-Like Behavior Restricted to the Female GenderSemantic proximity Read ↗

Acute rapamycin rescues the hyperexcitable phenotype of accumbal medium spiny neurons in the valproic acid rat model of autism spectrum disorder.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.