Article

Unveiling causal regulatory mechanisms through cell-state parallax

2023-03-03

Abstract excerpt

Genome-wide association studies (GWAS) identify numerous disease-linked genetic variants at noncoding genomic loci, yet therapeutic progress is hampered by the challenge of deciphering the regulatory roles of these loci in tissue-specific contexts. Single-cell multimodal assays that simultaneously profile chromatin accessibility and gene expression could predict tissue-specific causal links between noncoding loci...

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Literature Corpus work: d5e8f6a9-2fac-5e25-802a-272ebc52d2a6
DOI: 10.1101/2023.03.02.530529

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