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Article

Unveiling causal regulatory mechanisms through cell-state parallax.

Nature communications - 29 Aug 2025

Wu Alexander P, Singh Rohit, Walsh Christopher A, Berger Bonnie

Abstract excerpt

Genome-wide association studies (GWAS) identify numerous disease-linked genetic variants at noncoding genomic loci, yet therapeutic progress is hampered by the challenge of deciphering the regulatory roles of these loci in tissue-specific contexts. Single-cell multimodal assays that simultaneously profile chromatin accessibility and gene expression could predict tissue-specific causal links between noncoding loci...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40883263
DOI: 10.1038/s41467-025-61337-5
PMCID: PMC12397229

Genes

KCNG2
SLC12A6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Sept 2026.

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