Article

miR-425-5p Regulates Cellular Senescence Through Modulation of Retinoblastoma Protein Phosphorylation

2026-06-19

Abstract excerpt

MicroRNAs (miRNAs) are small non-coding RNAs that play critical roles in regulating cellular senescence and aging. Our recent studies identified a conserved C. elegans miRNA cluster (miR-229/64/65/66) that is required for normal adult lifespan, with overexpression significantly extending longevity. Notably, cel-miR-229 is evolutionarily conserved in humans, with hsa-miR-425 sharing an identical seed sequence. He...

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Literature Corpus work: d5d85c0b-b56c-5180-abac-2c56cc6f8436
DOI: 10.64898/2026.06.15.732173

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