Article

Loss of Cdk5rap2 triggers cellular senescence via β-catenin-mediated downregulation of WIP1

2020-07-11

Abstract excerpt

Loss-of-function mutations in Cdk5rap2 is associated with the developmental disorders, primary microcephaly and primordial dwarfism, but the underlying molecular link remains obscure. Here, we show that Cdk5rap2 loss in BJ-5ta human fibroblasts triggers senescence that is associated with proliferation defect, which is manifested as small body size in Cdk5rap2 an/an mice. In fibroblasts, Cdk5rap2 loss induces p53...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: deb40538-e639-5d5b-8b71-6d7d28bafbe9
DOI: 10.1101/2020.07.09.194761

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Loss of Cdk5rap2 triggers cellular senescence via β-catenin-mediated downregulation of WIP1DOI 10.1101/2020.07.09.194761Read

WIPI proteins: Biological functions and related syndromesSemantic proximity Read

miR-425-5p Regulates Cellular Senescence Through Modulation of Retinoblastoma Protein PhosphorylationSemantic proximity Read

Wip1 phosphatase: between p53 and MAPK kinases pathways.Semantic proximity Read

The type 2C phosphatase Wip1: An oncogenic regulator of tumor suppressor and DNA damage response pathwaysSemantic proximity Read

Pontin-deficiency causes senescence in fibroblast cells and epidermal keratinocytes but induces apoptosis in cancer cells.Semantic proximity Read

Mice Deficient for the Wild-Type p53-Induced Phosphatase Gene (<i>Wip1</i>) Exhibit Defects in Reproductive Organs, Immune Function, and Cell Cycle ControlSemantic proximity Read

Regulation of the Wip1 phosphatase and its effects on the stress response Julie Lowe, Hyukjin Cha, Mi-Ok Lee, Sharlyn J. Mazur, Ettore Appella, Albert J. Fornace Jr.Semantic proximity Read

Wip1 phosphatase in breast cancer.Semantic proximity Read

CDKN2B deletion is essential for pancreatic cancer development instead of unmeaningful co-deletion due to juxtaposition to CDKN2ASemantic proximity Read

PPM1D is a neuroblastoma oncogene and therapeutic target in childhood neural tumorsSemantic proximity Read

Human WIPI β-propeller function in autophagy and neurodegeneration.Semantic proximity Read

Comprehensive analysis of autophagic functions of WIPI family proteins and their implications for the pathogenesis of β-propeller associated neurodegenerationSemantic proximity Read