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Article

miR-127 Regulates Cell Proliferation and Senescence by Targeting BCL6

25 Nov 2013

Abstract excerpt

Cellular senescence occurs as a response to extracellular and intracellular stresses and contributes to aging and age-related pathologies. Emerging evidence suggests that cellular senescence also acts as a potent tumor suppression mechanism that prevents the oncogenic transformation of primary human cells. Recent reports have indicated that miRNAsact as key modulators of cellular senescence by targeting critical...

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PMID: 24282530
DOI: 10.1371/journal.pone.0080266

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