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Article

MicroRNA-191 triggers keratinocytes senescence by SATB1 and CDK6 downregulation

5 Jun 2012

Abstract excerpt

Keratinocyte replicative senescence has an important role in time-dependent changes of the epidermis, a tissue with high turnover. Senescence encompasses growth arrest during which cells remain metabolically active but acquire a typical enlarged, vacuolar and flattened morphology. It is also accompanied by the expression of endogenous senescence-associated-β-galactosidase and specific gene expression profiles....

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Share to Epigenetics and DNA Methylation
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PMID: 22683624
DOI: 10.1016/j.bbrc.2012.05.153

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