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Article

MicroRNA profiling in human diploid fibroblasts uncovers miR-519 role in replicative senescence

19 Jun 2010

Abstract excerpt

MicroRNAs (miRNAs) are short non-coding RNAs that regulate diverse biological processes by controlling the pattern of expressed proteins. In mammalian cells, miRNAs partially complement their target sequences leading to mRNA degradation and/or decreased mRNA translation. Here, we have analyzed transcriptome-wide changes in miRNAs in senescent relative to early-passage WI-38 human diploid fibroblasts (HDFs). Among...

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PMID: 20606251
DOI: 10.18632/aging.100159

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