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Article

p35 Is Required for CDK5 Activation in Cellular Senescence

24 Feb 2010

Abstract excerpt

The retinoblastoma tumor suppressor gene (RB-1) is a key regulator of cellular senescence. Expression of the retinoblastoma protein (pRB) in human tumor cells that lack it results in senescence-like changes. The induction of the senescent phenotype by pRB requires the postmitotic kinase CDK5, the best known function of which is in neuronal development and postmitotic neuronal activities. Activation of CDK5 in...

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PMID: 20181942
DOI: 10.1074/jbc.m109.066118

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