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Impact of Cancer-Associated Mutations in Hsh155/SF3b1 HEAT Repeats 9-12 on pre-mRNA Splicing in <i>Saccharomyces cerevisiae</i>

2020-02-05

Abstract excerpt

Mutations in the splicing machinery have been implicated in a number of human diseases. Most notably, the U2 small nuclear ribonucleoprotein (snRNP) component SF3b1 has been found to be frequently mutated in blood cancers such as myelodysplastic syndromes (MDS). SF3b1 is a highly conserved HEAT repeat (HR)-containing protein and most of these blood cancer mutations cluster in a hot spot located in HR4-8. Recently,...

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Literature Corpus work
d5c3dac9-fe10-5da8-b1dc-8553f7b02186
DOI
10.1101/2020.02.05.935452
Open publication

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Impact of Cancer-Associated Mutations in Hsh155/SF3b1 HEAT Repeats 9-12 on pre-mRNA Splicing in <i>Saccharomyces cerevisiae</i>DOI 10.1101/2020.02.05.935452
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