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Article

Characterization of the SF3B1-SUGP1 interface reveals how numerous cancer mutations cause mRNA missplicing.

Genes & development - 26 Dec 2023

Zhang Jian, Xie Jindou, Huang Ji, Liu Xiangyang, Xu Ruihong, Tholen Jonas, Galej Wojciech P, Tong Liang, Manley James L, Liu Zhaoqi

Abstract excerpt

The spliceosomal gene SF3B1 is frequently mutated in cancer. While it is known that SF3B1 hotspot mutations lead to loss of splicing factor SUGP1 from spliceosomes, the cancer-relevant SF3B1-SUGP1 interaction has not been characterized. To address this issue, we show by structural modeling that two regions flanking the SUGP1 G-patch make numerous contacts with the region of SF3B1 harboring hotspot mutations....

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Identifiers

PMID: 37977822
DOI: 10.1101/gad.351154.123
PMCID: PMC10760632

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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