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Long-read transcriptome sequencing of CLL and MDS patients uncovers molecular effects of <i>SF3B1</i> mutations

2024-01-26

Abstract excerpt

<h4>Background</h4> Mutations in splicing factor 3B subunit 1 ( SF3B1 ) frequently occur in patients with chronic lymphocytic leukemia (CLL) and myelodysplastic syndromes (MDS). These mutations have a different effect on the disease prognosis with beneficial effect in MDS and worse prognosis in CLL patients. A full-length transcriptome approach can expand our knowledge on SF3B1 mutation effects on RNA splicing...

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Literature Corpus work
e9a10423-8c1c-5ade-9fe9-30c14f915555
DOI
10.1101/2024.01.26.576051
Open publication

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Long-read transcriptome sequencing of CLL and MDS patients uncovers molecular effects of <i>SF3B1</i> mutationsDOI 10.1101/2024.01.26.576051
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