Article

Cus2 enforces the first ATP-dependent step of splicing by binding to yeast SF3b1 through a UHM-ULM interaction

2019-01-29

Abstract excerpt

<h4>ABSTRACT</h4> Stable recognition of the intron branchpoint by the U2 snRNP to form the pre-spliceosome is the first ATP-dependent step of splicing. Genetic and biochemical data from yeast indicate that Cus2 aids U2 snRNA folding into the stem IIa conformation prior to pre-spliceosome formation. Cus2 must then be removed by an ATP-dependent function of Prp5 before assembly can progress. However, the location f...

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Literature Corpus work: 4533b40f-7704-50ba-a744-9482af12f6a2
DOI: 10.1101/534347

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