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Article

Disclosing the Impact of Carcinogenic SF3b Mutations on Pre-mRNA Recognition Via All-Atom Simulations.

Biomolecules - 21 Oct 2019

Borišek Jure, Saltalamacchia Andrea, Gallì Anna, Palermo Giulia, Molteni Elisabetta, Malcovati Luca, Magistrato Alessandra

Abstract excerpt

The spliceosome accurately promotes precursor messenger-RNA splicing by recognizing specific noncoding intronic tracts including the branch point sequence (BPS) and the 3'-splice-site (3'SS). Mutations of Hsh155 (yeast)/SF3B1 (human), which is a protein of the SF3b factor involved in BPS recognition and induces altered BPS binding and 3'SS selection, lead to mis-spliced mRNA transcripts. Although these mutations...

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Identifiers

PMID: 31640290
DOI: 10.3390/biom9100633
PMCID: PMC6843770

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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