Article
Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations.
Molecular cell - 20 Oct 2016
Cretu Constantin, Schmitzová Jana, Ponce-Salvatierra Almudena, Dybkov Olexandr, De Laurentiis Evelina I, Sharma Kundan, Will Cindy L, Urlaub Henning, Lührmann Reinhard, Pena Vladimir
Abstract excerpt
SF3b is a heptameric protein complex of the U2 small nuclear ribonucleoprotein (snRNP) that is essential for pre-mRNA splicing. Mutations in the largest SF3b subunit, SF3B1/SF3b155, are linked to cancer and lead to alternative branch site (BS) selection. Here we report the crystal structure of a human SF3b core complex, revealing how the distinctive conformation of SF3b155's HEAT domain is maintained by multiple...
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