Article

B-cell receptor reconstruction from single-cell RNA-seq with VDJPuzzle

2017-08-26

Abstract excerpt

The B-cell receptor (BCR) performs essential functions for the adaptive immune system including recognition of pathogen-derived antigens. Cell-to-cell variability of BCR sequences due to V(D)J recombination and somatic hypermutation (SHM) necessitates single-cell characterization of BCR sequences. Single-cell RNA sequencing (scRNA-seq) presents the opportunity for simultaneous capture of the BCR sequence and trans...

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Literature Corpus work: f60e124f-8b40-5739-92d5-58fcfd46a500
DOI: 10.1101/181156

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