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Integrative single-cell multi-omics of CD19-CAR <sup>pos</sup> and CAR <sup>neg</sup> T cells suggest drivers of immunotherapy response in B-cell neoplasias

2024-01-26

Abstract excerpt

How phenotypic, clonal, and functional heterogeneity of CAR-T-cells impact clinical outcomes remain understudied. Here, we integrated clonal kinetics with transcriptomic heterogeneity resolved by single-cell omics to explore cellular dynamics response of both non-transduced (CAR neg ) and transduced (CAR pos )T-cells. CAR neg and CAR pos T-cells were longitudinally interrogated in the manufactured infusion pro...

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Literature Corpus work
a5551741-8423-5106-bf91-3775e8096e10
DOI
10.1101/2024.01.23.576878
Open publication

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Integrative single-cell multi-omics of CD19-CAR <sup>pos</sup> and CAR <sup>neg</sup> T cells suggest drivers of immunotherapy response in B-cell neoplasiasDOI 10.1101/2024.01.23.576878
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