Article

Common trajectories of highly effective CD19-specific CAR T cells identified by endogenous T cell receptor lineages

2021-12-08

Abstract excerpt

Current chimeric antigen receptor-modified (CAR) T cell therapy products are evaluated in bulk, without assessment of the possible heterogeneity in effector potential between cells. Conceivably, only a subset of the pre-infusion product differentiates into optimal effectors. We generated a comprehensive single-cell gene expression and T cell receptor (TCR) sequencing dataset using both pre- and post-infusion CD19-...

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Literature Corpus work: d370951f-6f12-5263-b631-15084a4774b5
DOI: 10.1101/2021.12.05.21266287

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