Article

Fine mapping of causal HLA variants using penalised regression

2010-01-01

Abstract excerpt

The identification of risk loci in the Human Leukocyte Antigen (HLA) region using single-SNP association tests has been hampered by the extent of linkage disequilibrium (LD). Penalised regression via Least Absolute Shrinkage and Selection Operator (LASSO) can be used as a method for selection of variables in multi-SNP analysis, and to deal with the problem of multi-collinearity among predictors. This method applie...

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Literature Corpus work: d5853e04-c537-5d8e-af66-41621feb435d
DOI: 10.25560/6145

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