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Article

SNP selection in genome-wide and candidate gene studies via penalized logistic regression.

Genetic epidemiology - 1 Dec 2010

Ayers Kristin L, Cordell Heather J

Abstract excerpt

Penalized regression methods offer an attractive alternative to single marker testing in genetic association analysis. Penalized regression methods shrink down to zero the coefficient of markers that have little apparent effect on the trait of interest, resulting in a parsimonious subset of what we hope are true pertinent predictors. Here we explore the performance of penalization in selecting SNPs as predictors...

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Identifiers

PMID: 21104890
DOI: 10.1002/gepi.20543
PMCID: PMC3410531

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