Article

Species-specific protein-protein interactions govern the humanization of the 20S proteasome in yeast

2022-06-21

Abstract excerpt

Yeast and humans share thousands of genes despite a billion years of evolutionary divergence. While many human genes can functionally replace their yeast counterparts, nearly half of the tested shared genes cannot. For example, most yeast proteasome subunits are humanizable, except subunits comprising the β-ring core, including β2 (HsPSMB7). We developed a high-throughput pipeline to humanize yeast proteasomes by...

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Literature Corpus work: 7e1d2888-2952-58ad-af59-bc57fa1f5a63
DOI: 10.1101/2022.06.20.496808

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