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In-depth Analysis of the Lid Subunits Assembly Mechanism in Mammals

31 May 2019

Abstract excerpt

The 26S proteasome is a key player in the degradation of ubiquitinated proteins, comprising a 20S core particle (CP) and a 19S regulatory particle (RP). The RP is further divided into base and lid subcomplexes, which are assembled independently from each other. We have previously demonstrated the assembly pathway of the CP and the base by observing assembly intermediates resulting from knockdowns of each...

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PMID: 31159305
DOI: 10.3390/biom9060213

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