Article

Alterations in Lysosomal, Glial and Neurodegenerative Biomarkers in Patients with Sporadic and Genetic Forms of Frontotemporal Dementia

2024-02-12

Abstract excerpt

<h4>Background</h4> Frontotemporal dementia (FTD) is the most common cause of early-onset dementia with 10-20% of cases caused by mutations in one of three genes: GRN , C9orf72 , or MAPT . To effectively develop therapeutics for FTD, the identification and characterization of biomarkers to understand disease pathogenesis and evaluate the impact of specific therapeutic strategies on the target biology as well a...

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Literature Corpus work: 3ddffcd5-ff0d-52d3-806b-d4aecba946d5
DOI: 10.1101/2024.02.09.579529

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