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Article

Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2

7 Apr 2017

Abstract excerpt

Adenosquamous lung tumours, which are extremely poor prognosis, may result from cellular plasticity. Here, we demonstrate lineage switching of KRAS+ lung adenocarcinomas (ADC) to squamous cell carcinoma (SCC) through deletion of Lkb1 (Stk11) in autochthonous and transplant models. Chromatin analysis reveals loss of H3K27me3 and gain of H3K27ac and H3K4me3 at squamous lineage genes, including Sox2, ΔNp63 and Ngfr....

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PMID: 28387316
DOI: 10.1038/ncomms14922

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