Article

SMAD4 nanobodies as tools for investigating SMAD structures and modulating SMAD function

2025-04-15

Abstract excerpt

<title>Abstract</title> <p>In the canonical TGF-β signaling pathway, SMADs are transducers of receptor-activated signals. These proteins contain two well-structured domains (MH1 and MH2 domains) connected by a long, functional, unstructured linker. Beyond the physiological role of TGF-β signaling, its dysregulation is implicated in several pathologies, with many disease-causing mutations clustering within the SMA...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d54e623e-4cc5-56ca-87c2-3505d19f8d63
DOI: 10.21203/rs.3.rs-6354474/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SMAD4 nanobodies as tools for investigating SMAD structures and modulating SMAD functionDOI 10.21203/rs.3.rs-6354474/v1Read

The Smads.Semantic proximity Read

Structural determinants of Smad function in TGF-β signaling.Semantic proximity Read

The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF‐β receptorsSemantic proximity Read

Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling.Semantic proximity Read

A short amino-acid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3Semantic proximity Read

Structural basis of Smad2 recognition by the Smad anchor for receptor activation.Semantic proximity Read

Mutations in protein-binding hot-spots on the hub protein Smad3 differentially affect its protein interactions and Smad3-regulated gene expression.Semantic proximity Read

Inhibition of TGF-β signaling at the nuclear envelope: characterization of interactions between MAN1, Smad2 and Smad3, and PPM1A.Semantic proximity Read

Structure-function relationship of inhibitory Smads: Structural flexibility contributes to functional divergence.Semantic proximity Read

PRMT5 methylating Smad4 activates TGF-β signaling and promotes colorectal cancer metastasisSemantic proximity Read

Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling.Semantic proximity Read

Suppression of TGF-β/SMAD signaling by an inner nuclear membrane phosphatase complexSemantic proximity Read