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Article

Inhibition of TGF-β signaling at the nuclear envelope: characterization of interactions between MAN1, Smad2 and Smad3, and PPM1A.

Science signaling - 18 Jun 2013

Bourgeois Benjamin, Gilquin Bernard, Tellier-Lebègue Carine, Östlund Cecilia, Wu Wei, Pérez Javier, El Hage Perla, Lallemand François, Worman Howard J, Zinn-Justin Sophie

Abstract excerpt

Signaling by transforming growth factor-β (TGF-β) is critical for various developmental processes and culminates in the activation of the transcription factors Smad2 and Smad3. MAN1, an integral protein of the inner nuclear membrane, inhibits TGF-β signaling by binding to Smad2 and Smad3. Depletion of the gene LEMD3 encoding MAN1 leads to developmental anomalies in mice, and heterozygous loss-of-function...

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Share to Bone Diseases, Developmental
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23779087
DOI: 10.1126/scisignal.2003411
PMCID: PMC3843637

Genes

LEMD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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